Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles
نویسندگان
چکیده
The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or C-5-aryl bonds were investigated by physical computational techniques. barrier was found be higher than that for rotation, confirming axial chirality stemming from an bond in a the most suitable development triazole-based platform.
منابع مشابه
SBA-15-supported-dithizone-copper(I): An efficient heterogeneous catalyst for synthesis of 1,4-disubstituted 1,2,3-triazoles in water
In this work, the SBA-15-supported dithizone-copper(I) [SBA-15-dtz–Cu(I)] complex as a new heterogeneous catalyst is prepared for the first time. The catalyst prepared is characterized by the FT-IR spectroscopy, SEM, and ICP techniques. This reusable heterogeneous catalyst can be used in the click reactions for the green and facile synthesis of 1,4-disubstituted 1,2,3-triazolesvia a on...
متن کاملSynthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
ABSTRACT By cycloaddition reaction of sodium azide with chalcone in the presence of CuO as a catalyst in DMF a 1,2,3-triazole are prepared in reaction with pentafluoropyridine to give 2-(tetrafluoropyridin-4-yl)-1,2,3-triazole derivatives in good yields and high regioselectivity. The regioselectivity of the compounds are confirmed by 19F-NMR and other spectroscopy. GRAPHICAL ABSTRACT
متن کاملGas Chromatographic Enantiomer Separation of Atropisomeric PCBs Using Modified Cyclodextrins as Chiral Phases
Columns containing different types of cyclodextrin derivatives have been evaluated for chiral gas chromatographic separation of atropisomeric PCBs, o,p9-DDT and o,p9-DDD. Separation was attempted on columns containing mixed chiral selectors, and the performance of two closely related selectors was also examined. The cyclodextrins were: permethylated-b-CD (PM-b-CD), heptakis(2,3-di-O-methyl-6O-t...
متن کاملOne-pot multicomponent click synthesis of some novel 1,4-disubstituted-1H-1,2,3-triazoles from alkenes
A facile and one-pot multicomponent synthesis of novel 1,4-disubstituted-1H-1,2,3-triazoles from alkenes at room temperature is reported. At the first step, in the presence of I2/NaN3 reagents, various alkenes were converted to the corresponding azido iodides and in the next step, the reaction of these compounds with phenylacetylene in the presence of catalytic amount of sodium ascorbate/ CuSO4...
متن کاملAn Efficient Synthesis of 1,4-Disubstituted Triazoles in Water via CuCl2/Zn-Catalyzed Huisgen Cycloaddition
Triazoles are an important class of heterocyclic compounds. In recent years 1,2,3-triazoles gained more and more interest due to their diverse biological activities and synthetic methodology [1 – 3]. An efficient approach for constructing the 1,2,3-triazole unit is the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, which was discovered independently by the groups of Sharpless ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tetrahedron chem
سال: 2022
ISSN: ['2666-951X']
DOI: https://doi.org/10.1016/j.tchem.2021.100004